SCHEMBL7096042

SCHEMBL7096042

CCN(CC)CCn1c(=O)c2cccnc2s/c1=N\c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.52
TP53 P04637 1/20 0.48
ALDH1A1 P00352 2/20 0.45
NSD2 O96028 1/20 0.45
MPO P05164 1/20 0.45
TOP2A P11388 1/20 0.41
KMT2A Q03164 2/20 0.40
SMN1; SMN2 Q16637 3/20 0.39
NPC1 O15118 2/20 0.38
POLB P06746 2/20 0.38
RAD52 P43351 2/20 0.38
RAB9A P51151 2/20 0.38
GAA P10253 1/20 0.38
SMARCA2 P51531 1/20 0.38
KAT2B Q92831 2/20 0.38
HIF1A Q16665 1/20 0.38
MITF O75030 1/20 0.36
DNMT1 P26358 1/20 0.36
HTT P42858 1/20 0.36
UHRF1 Q96T88 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7096044 1.00 KDM4E (0.52) KDM4ETP53ALDH1A1NSD2MPO
Hydrochloric Acid SCHEMBL7099337 0.91 KDM4E (0.49) KDM4ETP53ALDH1A1NSD2MPO
Hydrochloric Acid SCHEMBL7099336 0.91 KDM4E (0.49) KDM4ETP53ALDH1A1NSD2MPO
Hydrochloric Acid SCHEMBL7096530 0.88 KDM4E (0.47) KDM4ETP53ALDH1A1NSD2MPO
Hydrochloric Acid SCHEMBL7097432 0.88 KDM4E (0.47) KDM4ETP53ALDH1A1NSD2MPO
SCHEMBL7102653 0.88 KAT2B (0.41) KDM4ETP53ALDH1A1SMN1; SMN2POLB
SCHEMBL7102651 0.88 KAT2B (0.41) KDM4ETP53ALDH1A1SMN1; SMN2POLB
SCHEMBL7099625 0.86 MAPT (0.49) KDM4EALDH1A1KMT2ASMN1; SMN2NPC1
SCHEMBL7099626 0.86 MAPT (0.49) KDM4EALDH1A1KMT2ASMN1; SMN2NPC1
SCHEMBL7096644 0.85 KAT2B (0.43) KDM4EALDH1A1KMT2ASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0878196-B1 KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES YAMANOUCHI PHARMA CO LTD (JP) 2003-09-03 EP disclosed
US-6133258-A PYRIDOTHIAZINE DERIVATIVE; FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, PAIN, GLAUCOMA YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 2000-10-17 US disclosed
EP-0878196-A1 KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1998-11-18 EP disclosed