Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096459 | 1.00 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL7096508 | 0.88 | SMN1; SMN2 (0.49) | MEN1KMT2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL7096507 | 0.88 | SMN1; SMN2 (0.49) | MEN1KMT2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL7096656 | 0.86 | KAT2B (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL7096657 | 0.86 | KAT2B (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL7101446 | 0.85 | KAT2B (0.54) | MEN1KMT2ASMN1; SMN2RAB9AHPGD | |
| SCHEMBL7101449 | 0.85 | KAT2B (0.54) | MEN1KMT2ASMN1; SMN2RAB9AHPGD | |
| SCHEMBL7096970 | 0.84 | MAPT (0.52) | SMN1; SMN2MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL7096971 | 0.84 | MAPT (0.52) | SMN1; SMN2MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL7097105 | 0.84 | MAPT (0.49) | MEN1KMT2AMAPTRECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878196-B1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6133258-A | PYRIDOTHIAZINE DERIVATIVE; FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, PAIN, GLAUCOMA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0878196-A1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |