Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.45 |
| ▸ | RORA | P35398 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | RORB | Q92753 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096516 | 1.00 | MAPT (0.47) | MAPTPGRRORARORCRORB | |
| SCHEMBL7099357 | 0.93 | KAT2B (0.46) | MAPTPGRRORARORCRORB | |
| SCHEMBL7099355 | 0.93 | KAT2B (0.46) | MAPTPGRRORARORCRORB | |
| SCHEMBL7099626 | 0.91 | MAPT (0.49) | MAPTPGRRORARORCRORB | |
| SCHEMBL7099625 | 0.91 | MAPT (0.49) | MAPTPGRRORARORCRORB | |
| SCHEMBL7099943 | 0.89 | KAT2B (0.47) | MAPTHTTKAT2BTDP1L3MBTL1 | |
| SCHEMBL7099940 | 0.89 | KAT2B (0.47) | MAPTHTTKAT2BTDP1L3MBTL1 | |
| SCHEMBL7096406 | 0.89 | KAT2B (0.47) | MAPTHTTKAT2BPDE4APDE4B | |
| SCHEMBL7096404 | 0.89 | KAT2B (0.47) | MAPTHTTKAT2BPDE4APDE4B | |
| Hydrochloric Acid SCHEMBL7099337 | 0.85 | KDM4E (0.49) | KAT2BKMT2APOLBNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878196-B1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6133258-A | PYRIDOTHIAZINE DERIVATIVE; FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, PAIN, GLAUCOMA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0878196-A1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |