Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ITGAV | P06756 | 5/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL8722272 | 1.00 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL7561649 | 0.84 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL12326089 | 0.81 | PLK1 (0.54) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL2647552 | 0.81 | EPHX2 (0.48) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL2647548 | 0.81 | EPHX2 (0.48) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL20392869 | 0.81 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL8507006 | 0.81 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL3377096 | 0.81 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL8506869 | 0.81 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL24324149 | 0.79 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682660-B1 | SYNTHESIS OF TAXOL, ANALOGS AND INTERMEDIATES WITH VARIABLE A-RING SIDE CHAINS | BRYN MAWR COLLEGE (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6509484-B2 | Trifluoroacetic acid amine salt taxane derivatives useful for taxol production | NAPRO BIOTHERAPEUTICS, INC. | 2003-01-21 | — | — | US | disclosed |
| EP-1260507-A1 | Synthesis of taxol, analogs and intermediates with variable A-nng side chains | BRYN MAWR COLLEGE (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020052517-A1 | Synthesis of taxol, taxol analogs and their intermediates with variable a-ring side chain structures and compositions thereof | SWINDELL CHARLES S (US) | 2002-05-02 | — | — | US | disclosed |
| US-6307088-B1 | O-HYDROCARBYL N-(1-SUBSTITUTED-2-ALKOXYCARBONYL-2-(OPTIONALLY PROTECTED HYDROXY)ETHYL)CARBAMATE | NAPRO BIOTHERAPEUTICS, INC. | 2001-10-23 | — | — | US | disclosed |
| US-6262281-B1 | ANTICANCER AGENT | BRYN MAWR COLLEGE | 2001-07-17 | — | — | US | disclosed |
| CN-1284501-A | Compound for synthetic taxol, taxol analog and intermediate | BILEYMORE COLLEGE (US) | 2001-02-21 | — | — | CN | disclosed |
| US-6072060-A | Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof | BRYN MAWR COLLEGE (US) | 2000-06-06 | — | — | US | disclosed |
| US-5939566-A | ESTERIFICATION OF TAXANE WITH CARBAMOYL ACID DERIVATIVE | BRYN MAWR COLLEGE (US) | 1999-08-17 | — | — | US | disclosed |
| US-5770745-A | CHEMICAL CONDENSATION OF ESTERIFICATION | BRYN MAWR COLLEGE (US) | 1998-06-23 | — | — | US | disclosed |
| EP-0682660-A4 | — | — | 1995-12-20 | — | — | EP | disclosed |
| EP-0682660-A1 | SYNTHESIS OF TAXOL, ANALOGS AND INTERMEDIATES WITH VARIABLE A-RING SIDE CHAINS | BRYN MAWR COLLEGE (US) | 1995-11-22 | — | — | EP | disclosed |
| CN-1102829-A | Synthesis of taxol, taxol analogs and intermediates thereof and compositions thereof | BRYN MAWR COLLEGE (US) | 1995-05-24 | — | — | CN | disclosed |
| WO-1994018186-A1 | SYNTHESIS OF TAXOL, ANALOGS AND INTERMEDIATES WITH VARIABLE A-RING SIDE CHAINS | BRYN MAWR COLLEGE (US) | 1994-08-18 | — | — | WO | disclosed |
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052517-A1 | Synthesis of taxol, taxol analogs and their intermediates with variable a-ring side chain structures and compositions thereof | TUBA1A, TUBB1, TUBA1C | NPC1 1589/4885RAB9A 3002/4885SMN1; SMN2 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.