Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 9/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | KAT2A | Q92830 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096876 | 1.00 | GSK3B (0.42) | GSK3BALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7099729 | 0.88 | KAT2B (0.46) | ALDH1A1MAPTKDM4EKAT2BMAPK1 | |
| SCHEMBL7099733 | 0.88 | KAT2B (0.46) | ALDH1A1MAPTKDM4EKAT2BMAPK1 | |
| SCHEMBL7099114 | 0.84 | KAT2B (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4EKAT2B | |
| SCHEMBL7099117 | 0.84 | KAT2B (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4EKAT2B | |
| SCHEMBL7099839 | 0.82 | KAT2B (0.38) | ALDH1A1SMN1; SMN2MAPTKAT2BL3MBTL1 | |
| SCHEMBL7096479 | 0.82 | KAT2B (0.49) | SMN1; SMN2MAPTKDM4EKAT2BNPSR1 | |
| SCHEMBL7096481 | 0.82 | KAT2B (0.49) | SMN1; SMN2MAPTKDM4EKAT2BNPSR1 | |
| SCHEMBL7096926 | 0.82 | KAT2B (0.49) | ALDH1A1SMN1; SMN2MAPTKAT2BL3MBTL1 | |
| SCHEMBL7096924 | 0.82 | KAT2B (0.49) | ALDH1A1SMN1; SMN2MAPTKAT2BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878196-B1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6133258-A | PYRIDOTHIAZINE DERIVATIVE; FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, PAIN, GLAUCOMA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0878196-A1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |