Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.66 |
| ▸ | HTR2A | P28223 | 2/20 | 0.66 |
| ▸ | HTR2B | P41595 | 2/20 | 0.66 |
| ▸ | KDM1A | O60341 | 9/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 2/20 | 0.53 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096911 | 1.00 | HTR2C (0.66) | HTR2CHTR2AHTR2BKDM1AMAOA | |
| SCHEMBL7865958 | 1.00 | HTR2C (0.66) | HTR2CHTR2AHTR2BKDM1AMAOA | |
| Hydrochloric Acid SCHEMBL8156348 | 0.98 | HTR2C (0.67) | HTR2CHTR2AHTR2BKDM1AMAOA | |
| Hydrochloric Acid SCHEMBL8156350 | 0.98 | HTR2C (0.67) | HTR2CHTR2AHTR2BKDM1AMAOA | |
| Hydrochloric Acid SCHEMBL7000161 | 0.98 | HTR2C (0.67) | HTR2CHTR2AHTR2BKDM1AMAOA | |
| Hydrochloric Acid SCHEMBL7000158 | 0.98 | HTR2C (0.67) | HTR2CHTR2AHTR2BKDM1AMAOA | |
| SCHEMBL12971944 | 0.93 | HTR2A (0.59) | HTR2CHTR2AHTR2BKDM1AMAOA | |
| SCHEMBL8333649 | 0.83 | HTR2C (0.63) | HTR2CHTR2AHTR2BKDM1AMAOA | |
| SCHEMBL4253059 | 0.83 | HTR2C (0.55) | HTR2CHTR2AHTR2BKDM1ASLC9A1 | |
| SCHEMBL10263051 | 0.83 | HTR2C (0.55) | HTR2CHTR2AHTR2BKDM1ASLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174992-B2 | Heterobicyclic compounds | AMGEN INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174992-B2 | Heterobicyclic compounds | AMGEN INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174992-B2 | Heterobicyclic compounds | AMGEN INC. (US) | 2015-11-03 | — | — | US | disclosed |
| EP-2820014-A1 | HETEROBICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | Amgen Inc. (US) | 2015-01-07 | — | — | EP | disclosed |
| WO-2013130890-A1 | HETEROBICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | AMGEN INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| WO-2013130890-A1 | HETEROBICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | AMGEN INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| US-20130225552-A1 | HETEROBICYCLIC COMPOUNDS | AMGEN INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225552-A1 | HETEROBICYCLIC COMPOUNDS | AMGEN INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225552-A1 | HETEROBICYCLIC COMPOUNDS | AMGEN INC. (US) | 2013-08-29 | — | — | US | disclosed |
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225552-A1 | HETEROBICYCLIC COMPOUNDS | PDE10A, PDE1B, PDE9A | HTR2C 653/4885HTR2A 643/4885HTR2B 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.