Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.62 |
| ▸ | HTR2C | P28335 | 14/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099356 | 0.91 | HTR2A (0.59) | HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7097008 | 0.89 | HTR2A (0.65) | HTR2AHTR2CSIGMAR1KCNH2 | |
| SCHEMBL7097448 | 0.87 | HTR2A (0.60) | HTR2AHTR2CSIGMAR1 | |
| Hydrochloric Acid SCHEMBL7093513 | 0.85 | HTR2A (0.61) | HTR2AHTR2CKCNH2 | |
| Hydrochloric Acid SCHEMBL7093698 | 0.85 | HTR2A (0.63) | HTR2AHTR2CSIGMAR1KCNH2 | |
| SCHEMBL27515037 | 0.83 | HTR2A (0.61) | HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7094082 | 0.83 | HTR2A (0.60) | HTR2AHTR2CKCNH2 | |
| Hydrochloric Acid SCHEMBL7096632 | 0.81 | HTR2A (0.65) | HTR2AHTR2CSIGMAR1KCNH2 | |
| SCHEMBL7093241 | 0.81 | HTR2A (0.67) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL7099072 | 0.80 | HTR2A (0.69) | HTR2AHTR2CSIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194415-B1 | NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THEIR PREPARATION | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2003-08-20 | — | — | EP | disclosed |
| US-6469168-B1 | FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, ESPECIALLY ANXIETY | EGIS Gyógyszergyár Rt. (HU) | 2002-10-22 | — | — | US | disclosed |
| EP-1194415-A2 | NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THEIR PREPARATION | Egis Gyogyszergyar Rt. (HU) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001000617-A2 | NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE SAME | EGIS Gyógyszergyár Rt. (HU) | 2001-01-04 | — | — | WO | disclosed |