Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.58 |
| ▸ | HTR2C | P28335 | 6/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097243 | 1.00 | HTR2A (0.58) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6712406 | 0.89 | HTR2A (0.54) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6718508 | 0.89 | HTR2A (0.52) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6713772 | 0.89 | HTR2A (0.52) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6713779 | 0.89 | HTR2A (0.52) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6712095 | 0.88 | HTR2A (0.51) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6712099 | 0.88 | HTR2A (0.51) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6715441 | 0.88 | HTR2A (0.51) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6716207 | 0.84 | HTR2A (0.58) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL6718656 | 0.84 | HTR2A (0.58) | HTR2AHTR2CHTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328525-A2 | 2,3,4,5-TETRAHYDRO-1H-[1,4]DIAZEPINO[1,7-A]INDOLE COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 2003-07-23 | — | — | EP | claimed |
| WO-2001072752-A2 | 2,3,4,5-TETRAHYDRO-1H-[1,4]DIAZEPINO[1,7-a]INDOLE COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-04 | — | — | WO | claimed |