Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711995 | 0.87 | SCN9A (0.51) | SCN9AGAAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL710732 | 0.86 | SCN9A (0.63) | SCN9AGAAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL710624 | 0.86 | SCN9A (0.55) | SCN9AGAAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL712049 | 0.85 | SCN9A (0.54) | SCN9AGAAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL712299 | 0.81 | SCN9A (0.68) | SCN9AGAAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL712665 | 0.80 | SCN9A (0.61) | SCN9ASCN1ASCN5ASCN8ASCN3A | |
| SCHEMBL713597 | 0.80 | SCN9A (0.55) | SCN9ASCN1ASCN5ASCN8ASCN3A | |
| SCHEMBL714318 | 0.79 | SCN9A (0.65) | SCN9ASCN1ASCN5ASCN8A | |
| SCHEMBL712667 | 0.79 | SCN9A (0.65) | SCN9AALDH1A1SCN3A | |
| SCHEMBL712390 | 0.79 | SCN9A (0.55) | SCN9AGAAHPGDMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | claimed |
| EP-2173743-A2 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |