Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | PDE6D | O43924 | 1/20 | 0.43 |
| ▸ | PDE6A | P16499 | 1/20 | 0.43 |
| ▸ | PDE6G | P18545 | 1/20 | 0.43 |
| ▸ | PDE6B | P35913 | 1/20 | 0.43 |
| ▸ | PDE6C | P51160 | 1/20 | 0.43 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956721 | 0.89 | PDE5A (0.80) | PDE5APDE4BADORA1ADORA2APDE6D | |
| SCHEMBL7099558 | 0.88 | PDE5A (0.79) | PDE5APDE4BADORA1ADORA2APDE6D | |
| SCHEMBL7955430 | 0.86 | PDE5A (0.76) | PDE5APDE4BADORA1ADORA2APDE6D | |
| SCHEMBL7955247 | 0.85 | PDE5A (0.76) | PDE5APDE4BADORA1ADORA2APDE6D | |
| SCHEMBL7095381 | 0.84 | PDE5A (0.73) | PDE5APDE4BADORA1ADORA2APDE6D | |
| SCHEMBL7955490 | 0.84 | PDE5A (0.90) | PDE5APDE4BPDE6DPDE6APDE6G | |
| SCHEMBL1082869 | 0.84 | PDE5A (1.00) | PDE5APDE4BADORA1ADORA2APDE6D | |
| SCHEMBL7958799 | 0.84 | PDE5A (0.75) | PDE5APDE4BADORA1PDE6DPDE6A | |
| SCHEMBL7954881 | 0.84 | PDE5A (0.78) | PDE5APDE4BADORA1ADORA2APDE6D | |
| SCHEMBL7948019 | 0.83 | PDE5A (0.82) | PDE5APDE4BPDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1113796-A4 | FUSED PYRIDINE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2003-07-30 | — | — | EP | claimed |
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | claimed |
| EP-1113796-A1 | FUSED PYRIDINE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-07-11 | — | — | EP | claimed |
| WO-2000015222-A1 | FUSED PYRIDINE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-03-23 | — | — | WO | claimed |