Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 16/20 | 1.00 |
| ▸ | DRD2 | P14416 | 15/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14502883 | 1.00 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL8797434 | 1.00 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL6844226 | 1.00 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL5408639 | 1.00 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL5415647 | 1.00 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL14532740 | 1.00 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL5402861 | 1.00 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL7558449 | 0.93 | DRD4 (0.88) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL6905943 | 0.93 | DRD4 (0.88) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL6843875 | 0.92 | DRD4 (0.86) | DRD4DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116443-A1 | Dopamine D4 ligands for the treatment of novelty-seeking disorders | PFIZER INC | 2004-06-17 | — | — | US | claimed |
| US-7220753-B2 | 2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives as ligands for serotonin receptors | PFIZER INC. (US) | 2007-05-22 | — | — | US | disclosed |