Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.54 |
| ▸ | NOTCH3 | Q9UM47 | 2/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.52 |
| ▸ | CALCRL | Q16602 | 4/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005703 | 0.89 | PSEN1 (0.63) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL6006021 | 0.89 | PSEN1 (0.63) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL6003779 | 0.88 | PSEN1 (0.56) | KCNH2NOTCH1NOTCH3PSEN1PSEN2 | |
| SCHEMBL6006342 | 0.88 | PSEN1 (0.51) | KCNH2NOTCH1NOTCH3PSEN1PSEN2 | |
| SCHEMBL6006636 | 0.88 | PSEN1 (0.66) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL6005868 | 0.88 | PSEN1 (0.67) | KCNH2NOTCH1NOTCH3PSEN1PSEN2 | |
| SCHEMBL6004975 | 0.88 | PSEN1 (0.67) | KCNH2NOTCH1NOTCH3PSEN1PSEN2 | |
| SCHEMBL7095063 | 0.87 | PSEN1 (0.65) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL6005966 | 0.86 | PSEN1 (0.49) | KCNH2NOTCH1NOTCH3PSEN1PSEN2 | |
| SCHEMBL6003711 | 0.85 | PSEN1 (0.54) | KCNH2NOTCH1NOTCH3PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |