Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | CDK1 | P06493 | 16/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.69 |
| ▸ | CDK2 | P24941 | 11/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.63 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.61 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.61 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.61 |
| ▸ | CDK7 | P50613 | 6/20 | 0.60 |
| ▸ | CDK9 | P50750 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364042 | 0.83 | CDK1 (0.87) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL3332989 | 0.83 | CDK1 (0.76) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL17450111 | 0.82 | CDK1 (0.66) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL17450143 | 0.82 | CDK1 (0.66) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL1400442 | 0.81 | CDK1 (1.00) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL3851604 | 0.81 | TDP1 (0.78) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL4277404 | 0.81 | CDK1 (1.00) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL27562797 | 0.80 | CDK2 (0.77) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL2097195 | 0.80 | TDP1 (0.69) | KDM4ENPC1MAPTTDP1CDK1 | |
| SCHEMBL1216851 | 0.80 | TDP1 (0.69) | KDM4ENPC1MAPTTDP1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1308447-A1 | Purine derivatives having antiproliferative properties and biological uses thereof | Centre National de la Recherche Scientifique (C.N.R.S.) (FR) | 2003-05-07 | — | — | EP | claimed |
| EP-0874847-A1 | NOVEL PURINE DERIVATIVES HAVING, IN PARTICULAR, ANTIPROLIFERATIVE PROPERTIES, AND BIOLOGICAL USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-11-04 | — | — | EP | claimed |
| WO-1997020842-A1 | NOVEL PURINE DERIVATIVES HAVING, IN PARTICULAR, ANTIPROLIFERATIVE PROPERTIES, AND BIOLOGICAL USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 1997-06-12 | — | — | WO | claimed |