Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 6/20 | 0.46 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780177 | 0.80 | PDGFRB (0.62) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| SCHEMBL28693008 | 0.78 | PDGFRB (0.60) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| SCHEMBL3815563 | 0.78 | PDGFRB (0.60) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL8978256 | 0.77 | PDGFRB (0.58) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| SCHEMBL1998487 | 0.75 | PDGFRB (0.56) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| SCHEMBL28314061 | 0.75 | PDGFRB (0.56) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| SCHEMBL8610333 | 0.75 | PDGFRB (1.00) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| SCHEMBL27340469 | 0.75 | PDGFRB (0.56) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| SCHEMBL1998485 | 0.74 | PDGFRB (0.55) | PDGFRBPDGFRAALDH1A1KDM4EPOLB | |
| SCHEMBL1703116 | 0.74 | PDGFRB (0.65) | PDGFRBPDGFRAALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673937-B1 | BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES | EISAI CO LTD (JP) | 2003-11-26 | — | — | EP | disclosed |
| US-5767283-A | CHEMICAL INTERMEDIATE FOR 7-N-ORGANOSULFONYL-1H-INDOLE DERIVATIVE ANTITUMOR AGENTS; NONTOXIC | EISAI CO., LTD. (JP) | 1998-06-16 | — | — | US | disclosed |
| US-5721246-A | ANTITUMOR AGENTS; LOW TOXICITY | EISAI CO., LTD. (JP) | 1998-02-24 | — | — | US | disclosed |
| EP-0673937-A1 | BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |
| EP-0215200-B1 | USE OF SULFANILAMIDO QUINOXALINES IN THE TREATMENT OF NEOPLASTIC DISEASES | MERCK & CO. INC. (US) | 1992-09-09 | — | — | EP | disclosed |
| EP-0215200-A2 | Use of sulfanilamido quinoxalines in the treatment of neoplastic diseases | MERCK & CO. INC. (US) | 1987-03-25 | — | — | EP | disclosed |