Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099332 | 0.87 | NPC1 (0.78) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7099764 | 0.86 | NPC1 (1.00) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7097002 | 0.86 | NPC1 (0.76) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7099755 | 0.86 | NPC1 (0.76) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7102442 | 0.83 | NPC1 (0.71) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7095536 | 0.83 | NPC1 (0.71) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7095426 | 0.83 | NPC1 (0.75) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7097014 | 0.83 | NPC1 (0.71) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7101451 | 0.81 | NPC1 (0.68) | NPC1RAB9ALMNATSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7096065 | 0.80 | NPC1 (0.67) | NPC1RAB9ALMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878196-B1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6133258-A | PYRIDOTHIAZINE DERIVATIVE; FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, PAIN, GLAUCOMA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0878196-A1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |