Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 4/20 | 0.45 |
| ▸ | EP300 | Q09472 | 2/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.45 |
| ▸ | KAT2A | Q92830 | 2/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101196 | 1.00 | KAT2B (0.45) | KAT2BEP300CREBBPKAT2ATGM2 | |
| SCHEMBL7102769 | 0.90 | KAT2B (0.44) | KAT2BEP300CREBBPKAT2APTGDR2 | |
| SCHEMBL7102768 | 0.90 | KAT2B (0.44) | KAT2BEP300CREBBPKAT2APTGDR2 | |
| SCHEMBL7095386 | 0.86 | KMT2A (0.49) | KAT2BEP300CREBBPKAT2AKDM4E | |
| SCHEMBL7095388 | 0.86 | KMT2A (0.49) | KAT2BEP300CREBBPKAT2AKDM4E | |
| SCHEMBL7095419 | 0.86 | KAT2B (0.51) | KAT2BEP300CREBBPKAT2APTGDR2 | |
| SCHEMBL7095421 | 0.86 | KAT2B (0.51) | KAT2BEP300CREBBPKAT2APTGDR2 | |
| SCHEMBL7096021 | 0.86 | KAT2B (0.46) | KAT2BEP300CREBBPKAT2AADORA2A | |
| SCHEMBL7096022 | 0.86 | KAT2B (0.46) | KAT2BEP300CREBBPKAT2AADORA2A | |
| SCHEMBL7097091 | 0.85 | KAT2B (0.47) | KAT2BEP300CREBBPKAT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878196-B1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6133258-A | PYRIDOTHIAZINE DERIVATIVE; FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, PAIN, GLAUCOMA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0878196-A1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |