Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.72 |
| ▸ | HTR2B | P41595 | 5/20 | 0.72 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.62 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | NOX1 | Q9Y5S8 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5964738 | 0.99 | HTR2C (0.70) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| SCHEMBL7147484 | 0.84 | HTR2C (0.61) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| Hydrochloric Acid SCHEMBL5964363 | 0.84 | HTR2C (0.51) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| SCHEMBL7457165 | 0.84 | HTR2C (1.00) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| SCHEMBL5816607 | 0.83 | MAPT (0.57) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| SCHEMBL7095507 | 0.82 | HTR2C (0.72) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| Hydrochloric Acid SCHEMBL7661483 | 0.82 | HTR2C (0.97) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| Hydrochloric Acid SCHEMBL5964523 | 0.81 | HTR2C (0.70) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| SCHEMBL5810916 | 0.80 | HTR2B (0.58) | HTR2CHTR2BHCRTR1HCRTR2MAPT | |
| SCHEMBL5658555 | 0.78 | NPC1 (0.78) | HTR2CHTR2BMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075478-B1 | PHENYLUREA AND PHENYLTHIO UREA DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| US-6372757-B1 | OREXIN RECEPTORS FOR SLEEP DISORDERS AND EATING DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-16 | — | — | US | disclosed |