Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | APP | P05067 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | AGXT | P21549 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28550433 | 0.85 | MAOB (0.53) | MAOBAPPNPC1RAB9ATDP1 | |
| SCHEMBL17260899 | 0.82 | MAPT (0.43) | MAOBRAB9ATDP1HTR1ASMN1; SMN2 | |
| SCHEMBL7024020 | 0.81 | MAOB (0.53) | MAOBAPPNPC1RAB9ATDP1 | |
| SCHEMBL5568926 | 0.77 | TDP1 (0.44) | MAOBAPPNPC1RAB9ATDP1 | |
| SCHEMBL7015864 | 0.76 | TLR4 (0.48) | MAOBAPPNPC1RAB9ATDP1 | |
| SCHEMBL2451926 | 0.74 | APP (0.49) | MAOBAPPNPC1RAB9ATDP1 | |
| SCHEMBL160707 | 0.73 | — | — | |
| SCHEMBL21680729 | 0.73 | PTPN1 (0.38) | SMN1; SMN2 | |
| SCHEMBL159421 | 0.72 | NQO1 (0.36) | TDP1SMN1; SMN2 | |
| SCHEMBL6195407 | 0.71 | MAOB (0.51) | MAOBTDP1HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326856-A1 | PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-BETA) INHIBITING ACTIVITY | Bayer Aktiengesellschaft (DE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002024679-A1 | PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-β) INHIBITING ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-28 | — | — | WO | disclosed |