Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.69 |
| ▸ | JAK2 | O60674 | 5/20 | 0.62 |
| ▸ | JAK3 | P52333 | 5/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102850 | 1.00 | LCK (0.69) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7024692 | 0.93 | LCK (0.79) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7025767 | 0.92 | LCK (0.74) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7025844 | 0.88 | LCK (0.73) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7022331 | 0.87 | LCK (0.74) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7022090 | 0.85 | LCK (0.83) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7020879 | 0.83 | LCK (0.90) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7020628 | 0.83 | LCK (0.75) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7016983 | 0.83 | LCK (0.87) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7016740 | 0.82 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |