Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504314 | 0.87 | HDAC3 (0.46) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7696942 | 0.87 | NAMPT (0.48) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL504928 | 0.85 | CYP2C9 (0.40) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL504484 | 0.85 | CYP2C9 (0.40) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL504473 | 0.85 | CYP2C9 (0.40) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL504474 | 0.85 | CYP2C9 (0.40) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL504485 | 0.85 | CYP2C9 (0.40) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL504929 | 0.85 | CYP2C9 (0.40) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Chs-828 SCHEMBL504151 | 0.85 | NAMPT (0.61) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL505054 | 0.85 | NAMPT (0.61) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984938-B1 | CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS | LEO PHARMA AS WITH SECONDARY N (DK) | 2003-09-10 | — | — | EP | claimed |
| US-6346541-B1 | ANTITUMOR AND ANTICARCINOGENIC AGENTS FOR BREAST, LUNG, AND SKIN CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-02-12 | — | — | US | claimed |
| EP-0984938-B1 | CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS | LEO PHARMA AS WITH SECONDARY N (DK) | 2003-09-10 | — | — | EP | disclosed |
| US-6346541-B1 | ANTITUMOR AND ANTICARCINOGENIC AGENTS FOR BREAST, LUNG, AND SKIN CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-02-12 | — | — | US | disclosed |