SCHEMBL7104101

SCHEMBL7104101

NCCCCCCNC(=O)c1ccc(Cl)cc1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.75
TSHR P16473 1/20 0.75
NFKB1 P19838 1/20 0.75
MAOB P27338 1/20 0.75
MEN1 O00255 1/20 0.73
BLM P54132 1/20 0.73
PMP22 Q01453 1/20 0.73
KMT2A Q03164 1/20 0.73
HDAC3 O15379 2/20 0.66
HDAC1 Q13547 2/20 0.66
HDAC4 P56524 1/20 0.66
HDAC7 Q8WUI4 1/20 0.66
HDAC2 Q92769 1/20 0.66
HDAC10 Q969S8 1/20 0.66
HDAC11 Q96DB2 1/20 0.66
HDAC8 Q9BY41 1/20 0.66
HDAC6 Q9UBN7 1/20 0.66
HDAC9 Q9UKV0 1/20 0.66
HDAC5 Q9UQL6 1/20 0.66
NAMPT P43490 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27956896 1.00 CYP1A2 (0.75) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL6859638 0.93 CYP1A2 (0.80) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL9491749 0.91 HDAC3 (0.76) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL26709560 0.91 MAPK1 (0.65) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL12960847 0.91 MAPK1 (0.65) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL3523157 0.89 MAPK1 (0.61) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL3506361 0.86 MAOB (1.00) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL7010165 0.85 HDAC3 (0.68) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL7008066 0.85 HDAC3 (0.68) CYP1A2TSHRNFKB1MAOBMEN1
SCHEMBL13566561 0.85 MAPK1 (0.62) CYP1A2TSHRNFKB1MAOBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0984938-B1 CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS LEO PHARMA AS WITH SECONDARY N (DK) 2003-09-10 EP disclosed
US-6346541-B1 ANTITUMOR AND ANTICARCINOGENIC AGENTS FOR BREAST, LUNG, AND SKIN CANCER LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 2002-02-12 US disclosed
EP-0984938-A1 CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 2000-03-15 EP disclosed
WO-1998054144-A1 CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1998-12-03 WO disclosed