SCHEMBL7104569

SCHEMBL7104569

SC(c1ccccc1)c1cc(Cl)cc(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.55
TDO2 P48775 4/20 0.55
TACR1 P25103 4/20 0.41
ACP3 P15309 1/20 0.39
TSHR P16473 3/20 0.39
CNR2 P34972 1/20 0.38
ALDH1A1 P00352 4/20 0.37
KDM4E B2RXH2 1/20 0.37
GAA P10253 1/20 0.37
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29064053 0.81 IDO1 (0.59) IDO1TDO2TSHRLMNA
SCHEMBL132873 0.80 DPP4 (0.47) TSHRLMNA
Iodide SCHEMBL1043794 0.77 DPP4 (0.45) TSHRLMNA
Hydrochloric Acid SCHEMBL157812 0.77 DPP4 (0.45) IDO1TDO2TSHRALDH1A1
SCHEMBL27550444 0.77 DPP4 (0.45) TSHRLMNA
SCHEMBL3938201 0.77 CYP19A1 (0.51) IDO1TDO2TSHRALDH1A1LMNA
SCHEMBL17069289 0.73 IDO1 (0.50) IDO1TDO2TACR1ACP3TSHR
SCHEMBL17069291 0.73 IDO1 (0.50) IDO1TDO2TACR1ACP3TSHR
SCHEMBL17071879 0.73 IDO1 (0.50) IDO1TDO2TACR1ACP3TSHR
SCHEMBL17061776 0.73 IDO1 (0.50) IDO1TDO2TACR1ACP3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1044965-B1 PROCESS FOR THE PREPARATION OF AROMATIC SULFUR COMPOUNDS NIPPON FINECHEMICAL CO LTD (JP) 2003-10-01 EP disclosed
US-6444853-B1 FROM AROMATIC THIOETHER NIPPON FINECHEMICAL CO., LTD. (JP) 2002-09-03 US disclosed
US-6376716-B1 REACTING AN AROMATIC THIOETHER WITH LEWIS ACIDS; FORMING AROMATIC MERCAPTAN NIPPON FINECHEMICAL CO., LTD. (JP) 2002-04-23 US disclosed
EP-1044965-A1 PROCESS FOR THE PREPARATION OF AROMATIC SULFUR COMPOUNDS Nippon Finechemical Co., Ltd. (JP) 2000-10-18 EP disclosed