SCHEMBL7104692

SCHEMBL7104692

N#Cc1c(C2CCNCC2)cc(-c2c(O)cccc2OCC2CC2)nc1[AsH2]

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IKBKB O14920 20/20 0.80
CHUK O15111 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL30341860 0.90 IKBKB (0.98) IKBKBCHUK
SCHEMBL30337765 0.89 IKBKB (1.00) IKBKBCHUK
SCHEMBL1726425 0.89 IKBKB (1.00) IKBKBCHUK
SCHEMBL4601439 0.85 IKBKB (1.00) IKBKBCHUK
Hydrochloric Acid SCHEMBL4946607 0.85 IKBKB (0.72) IKBKBCHUK
SCHEMBL14028474 0.84 IKBKB (0.73) IKBKBCHUK
Hydrochloric Acid SCHEMBL4945309 0.80 IKBKB (0.98) IKBKBCHUK
SCHEMBL27791079 0.80 IKBKB (0.66) IKBKBCHUK
SCHEMBL14028397 0.80 IKBKB (1.00) IKBKBCHUK
SCHEMBL14028386 0.79 IKBKB (1.00) IKBKBCHUK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1326856-A1 PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-BETA) INHIBITING ACTIVITY Bayer Aktiengesellschaft (DE) 2003-07-16 EP claimed
WO-2002024679-A1 PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-β) INHIBITING ACTIVITY BAYER AKTIENGESELLSCHAFT (DE) 2002-03-28 WO claimed