Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.32 |
| ▸ | POLA1 | P09884 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104762 | 1.00 | EP300 (0.40) | EP300TSHREPHX1POLBLPAR1 | |
| SCHEMBL16295144 | 0.90 | EP300 (0.44) | EP300TSHRPOLBTERTGMNN | |
| SCHEMBL3589901 | 0.84 | — | — | |
| SCHEMBL9913422 | 0.84 | — | — | |
| SCHEMBL9718334 | 0.84 | EP300 (0.48) | EP300TSHREPHX1POLBTERT | |
| SCHEMBL4583581 | 0.84 | EP300 (0.48) | EP300TSHREPHX1POLBTERT | |
| SCHEMBL14721325 | 0.81 | EP300 (0.37) | EP300TSHRPOLBGMNNUSP2 | |
| SCHEMBL16782695 | 0.81 | EP300 (0.37) | EP300TSHRPOLBGMNNUSP2 | |
| SCHEMBL14721323 | 0.81 | EP300 (0.37) | EP300TSHRPOLBGMNNUSP2 | |
| SCHEMBL3933343 | 0.79 | EP300 (0.44) | EP300TSHREPHX1POLBTERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127886-B1 | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-2H-pyran-2one | HOFFMANN LA ROCHE (CH) | 2003-05-07 | — | — | EP | disclosed |
| US-6552204-B1 | Lactonization of an acyl halide and a ketene acetal or reacting acyl halide with malonate half acid then cyclizing; high yield | ROCHE COLORADO CORPORATION | 2003-04-22 | — | — | US | disclosed |
| CN-1319596-A | Synthesis of 3,6-dialkyl 5,6-dihydro-4-hydroxide-2H-pyran-2-ketone | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | CN | disclosed |
| EP-1127886-A1 | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-2H-pyran-2one | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-29 | — | — | EP | disclosed |