Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.35 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 5/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | VNN1 | O95497 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105013 | 1.00 | GSK3B (0.35) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5100119 | 0.83 | GSK3B (0.51) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL14097057 | 0.74 | GSK3B (0.49) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5022437 | 0.72 | GSK3B (0.46) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5023309 | 0.72 | GSK3B (0.49) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5092053 | 0.71 | GSK3B (0.69) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5100102 | 0.70 | GSK3B (0.51) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5091610 | 0.70 | GSK3B (0.53) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5089415 | 0.69 | KDM1A (0.42) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL4394527 | 0.67 | GSK3B (0.63) | GSK3BCCNB2CDK1CCNB1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |