Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28749912 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBSIRT2SIRT1ESR1 | |
| SCHEMBL27600113 | 0.87 | PSEN1 (0.47) | SMN1; SMN2SIRT2SIRT1ESR1ESR2 | |
| SCHEMBL7104337 | 0.87 | MAPT (0.42) | ALDH1A1SMN1; SMN2POLBMAPTSIRT2 | |
| SCHEMBL7099732 | 0.86 | TDP1 (0.44) | ALDH1A1SMN1; SMN2MAPTTSHRMEN1 | |
| SCHEMBL7097040 | 0.85 | ESR1 (0.40) | ALDH1A1SMN1; SMN2POLBSIRT2SIRT1 | |
| SCHEMBL27600105 | 0.84 | AKR1C3 (0.40) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL27600241 | 0.84 | POLB (0.48) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL27600103 | 0.83 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2MAPTSIRT2SIRT1 | |
| SCHEMBL27599829 | 0.83 | KMT2A (0.49) | ALDH1A1SMN1; SMN2POLBMAPTCNR2 | |
| SCHEMBL7098251 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2POLBMAPTESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1477960-A | EPA receptor inhibitors to treat rheumatoid arthritis | — | 2004-02-25 | — | — | CN | disclosed |
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |