Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 1.00 |
| ▸ | PLCG1 | P19174 | 10/20 | 0.74 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | BTK | Q06187 | 5/20 | 0.64 |
| ▸ | BMX | P51813 | 1/20 | 0.63 |
| ▸ | ITK | Q08881 | 3/20 | 0.60 |
| ▸ | CDC7 | O00311 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17939428 | 0.85 | PLCG1 (1.00) | JAK3PLCG1BTKITK | |
| SCHEMBL16151220 | 0.84 | BTK (0.74) | JAK3PLCG1BTKBMXITK | |
| SCHEMBL7974378 | 0.84 | JAK3 (0.73) | JAK3PLCG1CDC7 | |
| SCHEMBL17939331 | 0.81 | PLCG1 (1.00) | JAK3PLCG1BTKITK | |
| SCHEMBL17938946 | 0.81 | PLCG1 (0.85) | JAK3PLCG1BTKITK | |
| SCHEMBL17938938 | 0.80 | PLCG1 (0.80) | JAK3PLCG1BTKITK | |
| SCHEMBL17938855 | 0.80 | PLCG1 (0.76) | JAK3PLCG1BTKITK | |
| SCHEMBL17939632 | 0.80 | PLCG1 (0.77) | JAK3PLCG1BTKITK | |
| SCHEMBL17938947 | 0.79 | PLCG1 (0.82) | JAK3PLCG1BTKITK | |
| SCHEMBL16176905 | 0.79 | PLCG1 (0.75) | JAK3PLCG1EGFRBTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309590-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-05-14 | — | — | EP | disclosed |
| WO-2001098299-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | disclosed |