Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089391 | 0.84 | MAPK8 (0.46) | IKBKBMAPK8MAPK10CAMKK2GSK3B | |
| SCHEMBL5094140 | 0.81 | MAPK8 (0.48) | IKBKBCHUKMAPK8MAPK10CAMKK2 | |
| SCHEMBL5089535 | 0.80 | MKNK1 (0.50) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL27559787 | 0.79 | MAPK8 (0.43) | IKBKBCHUKMAPK8MAPK10CAMKK2 | |
| SCHEMBL5092137 | 0.79 | MAPK8 (0.46) | IKBKBCHUKMAPK8MAPK10CAMKK2 | |
| SCHEMBL5093422 | 0.78 | MAPK8 (0.57) | IKBKBCHUKMAPK8MAPK10CAMKK2 | |
| SCHEMBL5091983 | 0.77 | MAPK8 (0.61) | IKBKBCHUKMAPK8MAPK10CAMKK2 | |
| SCHEMBL5089083 | 0.76 | MKNK1 (0.47) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL7844380 | 0.74 | MAPK8 (0.53) | IKBKBCHUKMAPK8MAPK10CAMKK2 | |
| SCHEMBL5089454 | 0.74 | MAPK8 (0.53) | IKBKBCHUKMAPK8MAPK10CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |