SCHEMBL7106544

SCHEMBL7106544

CC(C)(C)OC(=O)N(CC=O)OC(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.36
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34
NR1H2 P55055 1/20 0.33
CTSD P07339 1/20 0.32
CTSL P07711 1/20 0.32
CTSB P07858 1/20 0.32
CTSS P25774 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.31
NFKB1 P19838 1/20 0.31
NFKB2 Q00653 1/20 0.31
RELA Q04206 1/20 0.31
CA14 Q9ULX7 1/20 0.31
CTSK P43235 1/20 0.31
USP2 O75604 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15488438 0.81 HDAC6 (0.37) HDAC6HDAC1HDAC2L3MBTL1NFKB1
SCHEMBL111602 0.78 CA14 (0.40) HDAC6HDAC1HDAC2CTSDCTSL
SCHEMBL4693101 0.78 HDAC6 (0.39) HDAC6HDAC1HDAC2NR1H2CTSD
SCHEMBL5500993 0.77 HDAC6 (0.33) HDAC6HDAC1HDAC2NFKB1NFKB2
SCHEMBL499275 0.76 HDAC6 (0.38) HDAC6HDAC1HDAC2CTSDCTSL
SCHEMBL5765810 0.74 HDAC6 (0.37) HDAC6HDAC1HDAC2CTSDCTSL
SCHEMBL28546389 0.74 HDAC6 (0.35) HDAC6HDAC1HDAC2CTSDCTSL
SCHEMBL1462541 0.73 CA14 (0.37) HDAC6HDAC1HDAC2L3MBTL1NFKB1
SCHEMBL22814762 0.73 HDAC6 (0.39) HDAC6HDAC1HDAC2NR1H2NFKB1
SCHEMBL1328517 0.73 HDAC6 (0.36) HDAC6HDAC1HDAC2CTSDCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0783507-B1 COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS AGOURON PHARMA (US) 2003-06-04 EP disclosed
US-5723607-A Compounds useful as antiproliferative agents and GARFT inhibitors AGOURON PHARMACETICALS, INC. (US) 1998-03-03 US disclosed
EP-0783507-A1 COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS AGOURON PHARMACEUTICALS, INC. (US) 1997-07-16 EP disclosed
US-5641774-A GLYCINAMIDE RIBONUCLEOTIDE FORMYL TRANSFERASE INHIBITORS; ANTITUMOR AGENTS AGOURON PHARMACEUTICALS, INC. (US) 1997-06-24 US disclosed
US-5641771-A FUSED AMIDINE-CONTAINING NITROGEN HETEROCYCLE COMPOUNDS AS ANTITUMOR AGENTS AGOURON PHARMACEUTICALS, INC. (US) 1997-06-24 US disclosed
US-5639749-A INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE FORMYL TRANSFERASE; ANTITUMOR AGENTS AGOURON PHARMACEUTICALS, INC. (US) 1997-06-17 US disclosed
US-5639747-A INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE FORMYL TRANSFERASE; ANTITUMOR AGENTS AGOURON PHARMACEUTICALS, INC. (US) 1997-06-17 US disclosed
US-5625061-A GRAFT=GLYCINAMIDE RIBONCLEOTIDE FORMYL TRANSFERASE AGOURON PHARMACEUTICALS, INC. (US) 1997-04-29 US disclosed
US-5610319-A Compound useful as antiproliferative agents and GARFT inhibitors AGOURON PHARMACEUTICALS, INC. (US) 1997-03-11 US disclosed
US-5594139-A FROM 5-HAL-2,6-DIAMINO-3H-4-OXOPYRIMIDINE AGOURON PHARMACEUTICALS, INC. (US) 1997-01-14 US disclosed
WO-1996003407-A1 COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS AGOURON PHARMACEUTICALS, INC. (US) 1996-02-08 WO disclosed