Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22497429 | 0.86 | KDM4E (0.74) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL30522452 | 0.86 | KDM4E (0.74) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL13936057 | 0.85 | KDM4E (0.74) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL31324947 | 0.85 | KDM4E (0.74) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL14426829 | 0.85 | KDM4E (0.74) | KDM4EKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL10497116 | 0.84 | HCAR2 (0.78) | KDM4ENPC1RAB9ASMN1; SMN2HCAR2 | |
| SCHEMBL15649049 | 0.84 | KDM4E (0.72) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL14227308 | 0.84 | KDM4E (0.72) | KDM4EKMT2AALDH1A1TSHRLMNA | |
| SCHEMBL9973826 | 0.83 | KDM4E (0.70) | KDM4EKMT2AALDH1A1TSHRLMNA | |
| SCHEMBL10502377 | 0.82 | KMT2A (1.00) | KDM4EKMT2AALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748910-B | Quinazolinone compound, preparation method and medical application thereof | 徐州医科大学 | 2021-04-30 | — | — | CN | disclosed |
| CN-109748910-A | A kind of quianzolinones, preparation method and medical usage | 徐州医科大学 | 2019-05-14 | — | — | CN | disclosed |
| EP-1439834-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003037328-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-05-08 | — | — | WO | disclosed |
| US-4994493-A | Treatment of cerebral edema | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN (DE) | 1991-02-19 | — | — | US | disclosed |