Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 18/20 | 0.46 |
| ▸ | PPARA | Q07869 | 15/20 | 0.46 |
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847993 | 0.88 | PPARD (0.57) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL5848523 | 0.87 | KDM4E (0.43) | PPARDPPARAPPARGKDM4EMEN1 | |
| SCHEMBL7103151 | 0.86 | PTPN1 (0.53) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL5849746 | 0.85 | PPARD (0.45) | PPARDPPARAPPARGFFAR1KDM4E | |
| SCHEMBL5848526 | 0.83 | PPARA (0.47) | PPARDPPARAPPARGFFAR1KDM4E | |
| SCHEMBL5848492 | 0.79 | PPARD (0.62) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL5848682 | 0.77 | PPARA (0.49) | PPARDPPARAPPARG | |
| SCHEMBL7107434 | 0.77 | PPARD (0.60) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL5847998 | 0.76 | PPARD (0.48) | PPARDPPARAPPARG | |
| SCHEMBL6473326 | 0.75 | PPARD (0.54) | PPARDPPARAPPARGFFAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345916-A1 | SUBSTITUTED OXAZOLES AND THIAZOLES AS HPPAR ALPHA AGONISTS | GLAXO GROUP LIMITED (GB) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050047-A1 | SUBSTITUED OXAZOLES AND THIAZOLES AS HPPAR ALPHA AGONISTS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |