Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.34 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11137906 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9APOLBHTT | |
| Bromide SCHEMBL8341147 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9APOLBHTT | |
| Bromide SCHEMBL8340477 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9APOLBHTT | |
| Bromide SCHEMBL11135085 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9APOLBHTT | |
| SCHEMBL10874106 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9APOLBHTT | |
| Hydrochloric Acid SCHEMBL7151438 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9APOLBHTT | |
| Hydrochloric Acid SCHEMBL8341355 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9APOLBHTT | |
| Iodide SCHEMBL8962414 | 0.80 | KDM4E (0.44) | SMN1; SMN2NPC1RAB9APOLBHTT | |
| SCHEMBL15153589 | 0.80 | SMN1; SMN2 (0.34) | SMN1; SMN2NPC1RAB9APOLBKDM4E | |
| SCHEMBL14562400 | 0.78 | POLB (0.35) | SMN1; SMN2NPC1RAB9APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6657768-B2 | Ion conductive layer formed by curing an ethenically unsaturated bipyridinium compound, an unsaturated metallocene such as vinylferrocene, and a solid electrolyte precursor such as a polyoxyalkylene glycol mono- or di- (meth)acrylate | NIPPON MITSUBISHI OIL CORPORATION (JP) | 2003-12-02 | — | — | US | disclosed |
| EP-1010741-B1 | Electrochromic device | NIPPON MITSUBISHI OIL CORP (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-20020136898-A1 | Electrochromic device | NIPPON MITSUBISHI OIL CORPORATION | 2002-09-26 | — | — | US | disclosed |
| EP-1010741-A2 | Electrochromic device | Nippon Mitsubishi Oil Corporation (JP) | 2000-06-21 | — | — | EP | disclosed |