SCHEMBL7111403

SCHEMBL7111403

COC(Cc1ccc(OCCN2CCCc3ccccc32)cc1)C(N)=O

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARG P37231 7/20 0.52
TSHR P16473 3/20 0.47
MAPT P10636 2/20 0.47
ALDH1A1 P00352 4/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
POLB P06746 1/20 0.45
HPGD P15428 1/20 0.45
CHRM2 P08172 4/20 0.45
CHRM4 P08173 4/20 0.45
CHRM1 P11229 4/20 0.45
CHRM3 P20309 4/20 0.45
PPARA Q07869 4/20 0.44
PPARD Q03181 3/20 0.44
GAA P10253 1/20 0.42
PKM P14618 1/20 0.42
PARP1 P09874 1/20 0.42
PARP2 Q9UGN5 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7035980 0.91 PPARG (0.61) PPARGTSHRMAPTALDH1A1MEN1
SCHEMBL7040474 0.90 PPARG (0.63) PPARGTSHRMAPTALDH1A1POLB
SCHEMBL7107208 0.84 PPARG (0.62) PPARGTSHRMAPTALDH1A1POLB
SCHEMBL7035857 0.83 PPARG (0.75) PPARGPPARAPPARD
SCHEMBL7106185 0.83 PPARG (0.63) PPARGTSHRMAPTALDH1A1POLB
SCHEMBL7110350 0.82 PPARG (0.53) PPARGTSHRMAPTALDH1A1MEN1
SCHEMBL7109727 0.81 PPARG (0.55) PPARGTSHRMAPTALDH1A1MEN1
SCHEMBL7105664 0.80 PPARG (0.52) PPARGTSHRMAPTALDH1A1MEN1
SCHEMBL7110525 0.80 PPARG (0.57) PPARGTSHRMAPTALDH1A1POLB
SCHEMBL7530774 0.79 PPARG (0.74) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003006022-A1 TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S LABORATORIES LTD. (IN) 2003-01-23 WO claimed
WO-2003006022-A1 TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S LABORATORIES LTD. (IN) 2003-01-23 WO disclosed