Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.47 |
| ▸ | SCN1A | P35498 | 3/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.44 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710732 | 0.89 | SCN9A (0.63) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL709717 | 0.89 | SCN9A (0.55) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL711689 | 0.87 | SCN9A (0.54) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL711730 | 0.87 | SCN9A (0.55) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL713142 | 0.86 | SCN9A (0.51) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL712466 | 0.84 | SCN9A (0.49) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL711584 | 0.84 | SCN9A (0.59) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL712667 | 0.84 | SCN9A (0.65) | SCN9ASCN3AMAPK14DDR2 | |
| SCHEMBL714318 | 0.82 | SCN9A (0.65) | SCN9ASCN1ASCN5ASCN8ASCN1B | |
| SCHEMBL708658 | 0.82 | SCN9A (0.47) | SCN9ASCN3ASCN1ASCN5ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | claimed |
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2393360-A1 | PYRIDAZINONE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090737-A1 | PYRIDAZINONE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-12 | — | — | WO | disclosed |
| EP-2173743-A2 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| US-20090023740-A1 | SODIUM CHANNEL INHIBITORS | ICAGEN (US) | 2009-01-22 | — | — | US | disclosed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023740-A1 | SODIUM CHANNEL INHIBITORS | TRPV1, SCN1A, SCN2A | SCN9A 17/4885SCN3A 7/4885MAPK14 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.