Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11621424 | 0.91 | SLC6A2 (0.48) | NOTUMSMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL22381380 | 0.86 | NPSR1 (0.48) | NOTUMSMN1; SMN2GRM7KMT2AMEN1 | |
| SCHEMBL3640973 | 0.82 | NOTUM (0.48) | NOTUMKMT2AMEN1HTTLMNA | |
| SCHEMBL3640969 | 0.82 | NOTUM (0.48) | NOTUMKMT2AMEN1HTTLMNA | |
| SCHEMBL4553227 | 0.81 | NOTUM (0.54) | NOTUMSMN1; SMN2GRM7KMT2AMEN1 | |
| SCHEMBL14432541 | 0.80 | SLC6A2 (0.46) | NOTUMSMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL19122068 | 0.80 | KMT2A (0.54) | NOTUMSMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL27715010 | 0.78 | SMN1; SMN2 (0.50) | NOTUMSMN1; SMN2GRM7KMT2AMEN1 | |
| SCHEMBL10203615 | 0.78 | NOTUM (0.51) | NOTUMSMN1; SMN2GRM7KMT2AMEN1 | |
| SCHEMBL10311200 | 0.77 | KMT2A (0.51) | NOTUMSMN1; SMN2GRM7KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006022-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-01-23 | — | — | WO | disclosed |