SCHEMBL7112489

SCHEMBL7112489

CC(C)n1cnc2c(NCc3ccccc3)nc(NCCCCO)nc21

nearest known ligand 0.94

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 16/20 0.94
CDK2 P24941 7/20 0.94
CCNB1 P14635 7/20 0.94
CCNB2 O95067 4/20 0.94
CCNB3 Q8WWL7 4/20 0.94
TDP1 Q9NUW8 2/20 0.94
CDK5 Q00535 7/20 0.86
CSNK1D P48730 1/20 0.86
CLK2 P49760 1/20 0.86
DYRK1A Q13627 1/20 0.86
HIPK4 Q8NE63 1/20 0.86
SRPK1 Q96SB4 1/20 0.86
CLK4 Q9HAZ1 1/20 0.86
KDM4E B2RXH2 1/20 0.80
NPC1 O15118 1/20 0.80
MAPT P10636 1/20 0.80
CCNE2 O96020 3/20 0.73
CCNE1 P24864 3/20 0.73
CCNA2 P20248 2/20 0.73
CCNA1 P78396 2/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7113555 0.99 CDK1 (0.92) CDK1CDK2CCNB1CCNB2CCNB3
Bohemine SCHEMBL1443403 0.97 CDK1 (1.00) CDK1CDK2CCNB1CCNB2CCNB3
Bohemine SCHEMBL29572816 0.97 CDK1 (1.00) CDK1CDK2CCNB1CCNB2CCNB3
SCHEMBL1216905 0.93 CDK1 (1.00) CDK1CDK2CCNB1CCNB2CCNB3
SCHEMBL24669662 0.89 TDP1 (0.81) CDK1CDK2CCNB1CCNB2CCNB3
SCHEMBL15940645 0.88 CDK2 (0.79) CDK1CDK2CCNB1CCNB2CCNB3
SCHEMBL31069517 0.87 TDP1 (0.87) CDK1CDK2CCNB1CCNB2CCNB3
SCHEMBL2183792 0.87 CDK2 (0.94) CDK1CDK2CCNB1CCNB2CCNB3
SCHEMBL2098182 0.86 CDK2 (0.88) CDK1CDK2CCNB1CCNB2CCNB3
SCHEMBL24668597 0.86 TDP1 (0.85) CDK1CDK2CCNB1CCNB2CCNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1353922-A1 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES Cancer Research Technology Limited (GB) 2003-10-22 EP disclosed
WO-2002059125-A1 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2002-08-01 WO disclosed
EP-1017394-A1 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2000-07-12 EP disclosed
WO-1999002162-A9 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER RES CAMPAIGN TECH (GB) 1999-07-29 WO disclosed
WO-1999002162-A1 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1999-01-21 WO disclosed