Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121500 | 0.87 | PDE10A (0.43) | PDE10APDE1APDE1BPDE1CATM | |
| Hydrochloric Acid SCHEMBL7118613 | 0.86 | PDE10A (0.42) | PDE10APDE1APDE1BPDE1CPDK1 | |
| SCHEMBL7211975 | 0.81 | PDE10A (0.48) | PDE10APDE1APDE1BPDE1CATM | |
| SCHEMBL7211972 | 0.81 | PDE10A (0.48) | PDE10APDE1APDE1BPDE1CATM | |
| SCHEMBL7210617 | 0.81 | PDE10A (0.43) | PDE10APDE1APDE1BPDE1CATM | |
| SCHEMBL7122691 | 0.81 | PARP1 (0.40) | NPC1RAB9ACTSAALDH1A1KDM4E | |
| SCHEMBL7583319 | 0.76 | PDE10A (0.43) | PDE10APDE1APDE1BPDE1CATM | |
| SCHEMBL7215272 | 0.72 | PDE10A (0.39) | PDE10APDE1APDE1BPDE1CATM | |
| SCHEMBL7215268 | 0.72 | PDE10A (0.39) | PDE10APDE1APDE1BPDE1CATM | |
| SCHEMBL7996483 | 0.71 | CYP2D6 (0.43) | ATMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030097000-A1 | 2-Phenyl-quinoline derivatives, preparation method and therapeutic use thereof | SANOFI-SYNTHELABO (FR) | 2003-05-22 | — | — | US | claimed |
| EP-1242381-A2 | 2-PHENYL-QUINOLINE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2002-09-25 | — | — | EP | claimed |
| WO-2001044197-A2 | 2-PHENYL-QUINOLINE DERIVATIVES AND THEIR USE AS CONTRACTING AGENT FOR SMOOTH MUSCLES | SANOFI-SYNTHELABO (FR) | 2001-06-21 | — | — | WO | claimed |
| US-20030097000-A1 | 2-Phenyl-quinoline derivatives, preparation method and therapeutic use thereof | SANOFI-SYNTHELABO (FR) | 2003-05-22 | — | — | US | disclosed |
| EP-1242381-A2 | 2-PHENYL-QUINOLINE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001044197-A2 | 2-PHENYL-QUINOLINE DERIVATIVES AND THEIR USE AS CONTRACTING AGENT FOR SMOOTH MUSCLES | SANOFI-SYNTHELABO (FR) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030097000-A1 | 2-Phenyl-quinoline derivatives, preparation method and therapeutic use thereof | CYP2F1, CYP4F2, CYP4F3 | PDE10A 2739/4885PDE1A 4009/4885PDE1B 3239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.