Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NDUFS8 | O00217 | 1/20 | 0.46 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.46 |
| ▸ | NDUFAB1 | O14561 | 1/20 | 0.46 |
| ▸ | NDUFA1 | O15239 | 1/20 | 0.46 |
| ▸ | NDUFS4 | O43181 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116251 | 1.00 | MAPT (0.57) | MAPTALOX5LMNAALDH1A1KDM4E | |
| SCHEMBL7109588 | 0.92 | MAPT (0.55) | MAPTALOX5LMNAALDH1A1KDM4E | |
| SCHEMBL7109585 | 0.92 | MAPT (0.55) | MAPTALOX5LMNAALDH1A1KDM4E | |
| SCHEMBL7114036 | 0.91 | MAPT (0.55) | MAPTALOX5LMNAALDH1A1KDM4E | |
| SCHEMBL7114031 | 0.91 | MAPT (0.55) | MAPTALOX5LMNAALDH1A1KDM4E | |
| SCHEMBL7114033 | 0.91 | MAPT (0.55) | MAPTALOX5LMNAALDH1A1KDM4E | |
| SCHEMBL4255038 | 0.87 | POLB (0.47) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL4704592 | 0.87 | POLB (0.47) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL7659576 | 0.87 | MAPT (0.62) | MAPTALOX5LMNAALDH1A1KDM4E | |
| SCHEMBL7659572 | 0.87 | MAPT (0.62) | MAPTALOX5LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1243730-C | Cinnamoylaminoalkyl-substd. benzenesulfonamide derivs. | AVENTIS PHARMA GMBH (DE) | 2006-03-01 | — | — | CN | disclosed |
| EP-1183236-B1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | AVENTIS PHARMA GMBH (DE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1183236-A1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| US-6350778-B1 | CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-02-26 | — | — | US | disclosed |
| WO-2000071513-A1 | CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-30 | — | — | WO | disclosed |