Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.43 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831921 | 0.94 | CA1 (0.53) | ACE2CA1FFAR1FFAR4GPR84 | |
| SCHEMBL21436875 | 0.87 | CA1 (0.57) | ACE2CA1FFAR1FFAR4GPR84 | |
| SCHEMBL21436874 | 0.87 | CA1 (0.57) | ACE2CA1FFAR1FFAR4GPR84 | |
| SCHEMBL28323830 | 0.85 | CA1 (0.55) | ACE2CA1FFAR1FFAR4GPR84 | |
| SCHEMBL1136757 | 0.77 | CA1 (0.55) | ACE2CA1FFAR1FFAR4GPR84 | |
| Ammonia Solution, Strong SCHEMBL27458793 | 0.77 | ACE2 (0.77) | ACE2CA1FFAR1FFAR4GPR84 | |
| Ammonia Solution, Strong SCHEMBL28016597 | 0.77 | ACE2 (0.77) | ACE2CA1FFAR1FFAR4GPR84 | |
| SCHEMBL10481806 | 0.76 | CA1 (0.44) | ACE2CA1FFAR1FFAR4GPR84 | |
| Oxalic Acid SCHEMBL19328779 | 0.75 | ACE2 (0.74) | ACE2CA1FFAR1FFAR4GPR84 | |
| Oxalic Acid SCHEMBL30604075 | 0.75 | CA1 (0.57) | ACE2CA1FFAR1FFAR4GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822248-B1 | Cleaning material for contact lens | MENICON CO LTD (JP) | 2003-11-12 | — | — | EP | disclosed |
| US-5919742-A | SOLID FORM; BLEND OF NONIONIC ADDITION POLYMER SURFACTANTS AND CROSSLINKING AGENT | MENICON CO., LTD. (JP) | 1999-07-06 | — | — | US | disclosed |
| EP-0822248-A2 | Cleaning material for contact lens | Menicon Co., Ltd. (JP) | 1998-02-04 | — | — | EP | disclosed |