Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.34 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6267687 | 0.90 | MAP2K1 (0.44) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6262794 | 0.86 | MAP2K1 (0.45) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6265052 | 0.79 | MAP2K1 (0.44) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6262801 | 0.78 | MAP2K1 (0.60) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6265165 | 0.76 | MAP2K1 (0.50) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6267654 | 0.76 | MAP2K1 (0.44) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6262702 | 0.75 | MAP2K1 (0.47) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6265539 | 0.74 | HSD17B10 (0.43) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6265425 | 0.74 | MAP2K1 (0.46) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6262746 | 0.74 | HTR2A (0.42) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |