Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125917 | 1.00 | JAK2 (0.36) | JAK2JAK1FLT3AURKBALDH1A1 | |
| SCHEMBL22034583 | 1.00 | JAK2 (0.36) | JAK2JAK1FLT3AURKBALDH1A1 | |
| SCHEMBL27416122 | 1.00 | JAK2 (0.36) | JAK2JAK1FLT3AURKBALDH1A1 | |
| SCHEMBL13945596 | 1.00 | JAK2 (0.36) | JAK2JAK1FLT3AURKBALDH1A1 | |
| SCHEMBL7125915 | 1.00 | JAK2 (0.36) | JAK2JAK1FLT3AURKBALDH1A1 | |
| SCHEMBL22262566 | 0.90 | JAK2 (0.35) | JAK2JAK1FLT3AURKBALDH1A1 | |
| SCHEMBL23489324 | 0.88 | JAK2 (0.35) | JAK2JAK1FLT3AURKBBCHE | |
| SCHEMBL17104749 | 0.88 | JAK2 (0.33) | JAK2JAK1FLT3AURKBBCHE | |
| SCHEMBL23489317 | 0.88 | JAK2 (0.35) | JAK2JAK1FLT3AURKBBCHE | |
| SCHEMBL23552541 | 0.85 | BCHE (0.35) | JAK2JAK1FLT3AURKBBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030212244-A1 | Polymers made from bis(2-hydroxyethyl)isosorbide and enduses thereof | HAYES RICHARD (US) | 2003-11-13 | — | — | US | disclosed |
| US-6608167-B1 | Heating isosorbide with a stoichiometric excess of ethylene carbonate in the presence of a catalyst | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-08-19 | — | — | US | disclosed |