Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 7/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120339 | 0.92 | EGFR (0.72) | EGFRERBB2ERBB4FLT1PIK3CA | |
| SCHEMBL7119446 | 0.88 | EGFR (0.56) | EGFRERBB2ERBB4FLT1KDR | |
| SCHEMBL7120477 | 0.86 | EGFR (0.63) | EGFRERBB2ERBB4FLT1KDR | |
| SCHEMBL7118108 | 0.84 | EGFR (0.85) | EGFRERBB2ERBB4 | |
| SCHEMBL7124503 | 0.81 | EGFR (0.71) | EGFRERBB2ERBB4FLT1PIK3CA | |
| SCHEMBL7117560 | 0.78 | EGFR (0.54) | EGFRERBB2ERBB4FLT1KDR | |
| SCHEMBL31514622 | 0.78 | EGFR (0.69) | EGFRERBB2FLT1KDRRET | |
| SCHEMBL7127858 | 0.78 | EGFR (0.58) | EGFRERBB2FLT1KDRRET | |
| Hydrochloric Acid SCHEMBL8976273 | 0.77 | EGFR (0.64) | EGFRERBB2FLT1KDRRET | |
| SCHEMBL7127863 | 0.77 | EGFR (0.57) | EGFRERBB2FLT1KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030087881-A1 | Irreversible inhibitors of tyrosine kinases | BRIDGES ALEXANDER JAMES (US) | 2003-05-08 | — | — | US | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-20030087881-A1 | Irreversible inhibitors of tyrosine kinases | BRIDGES ALEXANDER JAMES (US) | 2003-05-08 | — | — | US | disclosed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087881-A1 | Irreversible inhibitors of tyrosine kinases | ERBB2, ERBB3, LCK | EGFR 26/4885ERBB2 1/4885ERBB4 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.