Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.58 |
| ▸ | JAK1 | P23458 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 6/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12904539 | 0.89 | STAT6 (0.58) | JAK3JAK2JAK1PPARGSTAT6 | |
| SCHEMBL211691 | 0.86 | STAT6 (0.50) | JAK3JAK2JAK1PPARGSTAT6 | |
| SCHEMBL22261196 | 0.81 | JAK3 (0.55) | JAK3JAK2JAK1STAT6CCNA2 | |
| SCHEMBL14875573 | 0.80 | PPARG (0.45) | JAK3JAK2JAK1PPARGTHRB | |
| SCHEMBL447094 | 0.79 | KDR (0.59) | — | |
| SCHEMBL1522370 | 0.79 | PPARG (0.62) | PPARGSTAT6THRB | |
| SCHEMBL211407 | 0.78 | STAT6 (0.48) | JAK3JAK2JAK1STAT6THRB | |
| SCHEMBL211406 | 0.77 | HDAC1 (0.63) | — | |
| SCHEMBL2627145 | 0.77 | SYK (0.56) | — | |
| SCHEMBL7119744 | 0.77 | KDR (0.62) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |