Sugi Predict

Sugi Predict / Compounds / SCHEMBL712695

SCHEMBL712695

SCHEMBL712695

CC(C)Oc1cc(OCc2ccccc2)ccc1-c1nc2cc(Br)cnc2[nH]1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GCK P35557 4/20 0.39
▸ PDGFRB P09619 1/20 0.38
▸ PDGFRA P16234 1/20 0.38
▸ MAOB P27338 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ MCL1 Q07820 1/20 0.36
▸ MAOA P21397 1/20 0.36
▸ CYP3A4 P08684 1/20 0.36
▸ PTGES O14684 1/20 0.36
▸ HSP90AA1 P07900 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ ALOX5 P09917 1/20 0.36
▸ GABRP O00591 1/20 0.35
▸ GABRD O14764 1/20 0.35
▸ GABRA1 P14867 1/20 0.35
▸ GABRB1 P18505 1/20 0.35
▸ GABRG2 P18507 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL711734 0.92 GCK (0.39) GCKPDGFRBPDGFRAMAOBMCL1
SCHEMBL10206529 0.89 MAPT (0.41) PDGFRBPDGFRAMAOBKDM4EMAPT
SCHEMBL2668324 0.89 PDGFRB (0.38) GCKPDGFRBPDGFRAMAOBKDM4E
SCHEMBL711611 0.86 GCK (0.47) GCKKDM4EMCL1GABRPGABRD
SCHEMBL720489 0.86 MAPT (0.46) PDGFRBPDGFRAMAOBKDM4EMAPT
SCHEMBL713547 0.85 PRMT5 (0.39) PDGFRBPDGFRAKDM4EMAPTMCL1
SCHEMBL712826 0.85 MAP4K4 (0.43) MAPTMCL1MAPK1NPSR1
SCHEMBL712059 0.85 MCL1 (0.40) PDGFRBPDGFRAKDM4EMAPTMCL1
SCHEMBL9071894 0.85 CYP3A4 (0.46) PDGFRBPDGFRAMAOBMCL1MAOA
SCHEMBL710291 0.84 FFAR1 (0.37) PDGFRBPDGFRAKDM4EMAPTMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940837-B1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2012-11-07 — — EP disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
EP-1940837-A2 IMIDAZOPYRIDINE COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2008-07-09 — — EP disclosed
WO-2007028135-A2 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS GCK, GCKR, KHK GCK 1/4885PDGFRB 3099/4885PDGFRA 3259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.