Sugi Predict

Sugi Predict / Compounds / SCHEMBL712755

SCHEMBL712755

SCHEMBL712755

O=C(O)c1cnc2[nH]c(-c3cc(OCc4ccccc4)cc(OCc4ccccc4)c3)nc2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.53
▸ KMT2A Q03164 1/20 0.53
▸ GCK P35557 2/20 0.51
▸ CHEK2 O96017 1/20 0.49
▸ PDE4A P27815 1/20 0.46
▸ PDE4B Q07343 1/20 0.46
▸ PDE4C Q08493 1/20 0.46
▸ PDE4D Q08499 1/20 0.46
▸ EGLN1 Q9GZT9 2/20 0.46
▸ DHODH Q02127 4/20 0.45
▸ NR4A2 P43354 2/20 0.45
▸ NR4A1 P22736 1/20 0.45
▸ NR4A3 Q92570 1/20 0.45
▸ MRGPRX4 Q96LA9 1/20 0.44
▸ P2RY14 Q15391 1/20 0.42
▸ SRD5A2 P31213 2/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL712331 0.92 GCK (0.57) MEN1KMT2AGCKCHEK2PDE4A
SCHEMBL2668214 0.91 CHEK2 (0.48) MEN1KMT2AGCKCHEK2PDE4A
SCHEMBL710686 0.88 MAOB (0.49) MEN1KMT2ACHEK2ALDH1A1HPGD
SCHEMBL710664 0.84 DHODH (0.46) CHEK2EGLN1DHODHKDM4EALDH1A1
SCHEMBL2668328 0.83 CHEK2 (0.41) MEN1KMT2AGCKCHEK2PDE4A
SCHEMBL10206508 0.83 CSNK2A2 (0.47) MEN1KMT2AGCKCHEK2PDE4A
SCHEMBL709520 0.82 GCK (0.49) MEN1KMT2AGCKCHEK2ALDH1A1
SCHEMBL10206641 0.79 PRMT5 (0.51) MEN1KMT2ACHEK2DHODH
SCHEMBL710310 0.78 GCK (0.47) MEN1KMT2AGCKCHEK2PDE4A
Trifluoroacetic Acid SCHEMBL712106 0.78 CSNK2A2 (0.43) MEN1KMT2AGCKCHEK2PDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940837-B1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2012-11-07 — — EP disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-8124617-B2 Imidazopyridine compounds TAKEDA SAN DIEGO, INC. (US) 2012-02-28 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS TAKEDA SAN DIEGO, INC. 2010-03-18 — — US disclosed
EP-1940837-A2 IMIDAZOPYRIDINE COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2008-07-09 — — EP disclosed
WO-2007028135-A2 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069431-A1 IMIDAZOPYRIDINE COMPOUNDS GCK, GCKR, KHK MEN1 2868/4885KMT2A 2502/4885GCK 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.