Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.51 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL444751 | 0.99 | KDR (0.62) | KDRKDM4EMAPTSMN1; SMN2ABCB1 | |
| SCHEMBL4976797 | 0.87 | KDR (0.63) | KDRKDM4EMAPTSMN1; SMN2FLT1 | |
| SCHEMBL445500 | 0.83 | KDR (0.57) | KDRABCB1FLT1RETMAP3K20 | |
| SCHEMBL3151267 | 0.82 | KDR (0.64) | KDRKDM4E | |
| SCHEMBL427761 | 0.82 | KDR (0.58) | KDRABCB1FLT1RETMAP3K20 | |
| Hydrochloric Acid SCHEMBL446993 | 0.81 | KDR (0.57) | KDRABCB1FLT1RETMAP3K20 | |
| SCHEMBL446392 | 0.81 | KDR (0.66) | KDRKDM4EABCB1FLT1RET | |
| SCHEMBL7127183 | 0.81 | KDR (0.74) | KDRABCB1FLT1RETMAP3K20 | |
| Hydrochloric Acid SCHEMBL446959 | 0.80 | KDR (0.73) | KDRABCB1FLT1RETMAP3K20 | |
| SCHEMBL31362674 | 0.80 | KDR (0.69) | KDRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |