Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 9/20 | 0.47 |
| ▸ | HTR7 | P34969 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | HTR6 | P50406 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124485 | 0.97 | MEN1 (0.55) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7124621 | 0.93 | MEN1 (0.55) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7127386 | 0.92 | MEN1 (0.55) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7126175 | 0.91 | MEN1 (0.59) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7120774 | 0.89 | KMT2A (0.59) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7127345 | 0.89 | MEN1 (0.48) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7121915 | 0.89 | MEN1 (0.50) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7128611 | 0.89 | MEN1 (0.56) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7127553 | 0.88 | MEN1 (0.55) | MEN1RAB9AKMT2AMAPK1L3MBTL1 | |
| SCHEMBL7119849 | 0.88 | MEN1 (0.53) | MEN1RAB9AKMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667303-B1 | Agonists for serotonin 5-hydroxytryptamine 2C(5HT2C) receptor; 6-(1,4-diazepan-1-yl)benzo(cd)indol-2(1H)-ones, 6-(1,4-diazepan-1-yl)acenaphthylen-1(2H)-ones, and 5-(1,4-diazepan-1-yl)- 2H-naphtho(1,8-cd)isothiazole-1,1-dioxides | WYETH | 2003-12-23 | — | — | US | claimed |