Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 1.00 |
| ▸ | GSK3A | P49840 | 2/20 | 0.64 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.64 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.64 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.64 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.64 |
| ▸ | EEF2K | O00418 | 1/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.64 |
| ▸ | CLK2 | P49760 | 1/20 | 0.64 |
| ▸ | STK3 | Q13188 | 1/20 | 0.64 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.64 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.64 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857813 | 1.00 | AKT1 (1.00) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL6857809 | 1.00 | AKT1 (1.00) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL6853380 | 0.92 | AKT1 (1.00) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL6853377 | 0.92 | AKT1 (1.00) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL4660971 | 0.90 | AKT1 (0.81) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL4660981 | 0.90 | AKT1 (0.81) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL4659553 | 0.85 | AKT1 (0.85) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL4659556 | 0.85 | AKT1 (0.85) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL6849748 | 0.85 | AKT1 (1.00) | AKT1GSK3ARPS6KA3PRKCDDYRK1A | |
| SCHEMBL6855256 | 0.84 | AKT1 (0.73) | AKT1GSK3ARPS6KA3PRKCDDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | claimed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | claimed |