Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | BRD1 | O95696 | 1/20 | 0.44 |
| ▸ | TAF1 | P21675 | 1/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 8/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7129439 | 0.97 | CYP1B1 (0.45) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7130938 | 0.89 | CYP1B1 (0.49) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7121855 | 0.88 | MEN1 (0.56) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7128504 | 0.88 | MEN1 (0.55) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7130986 | 0.87 | CYP1B1 (0.55) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7126196 | 0.86 | MEN1 (0.53) | MEN1KMT2ARAB9AMAPK1NPC1 | |
| SCHEMBL7129206 | 0.86 | MEN1 (0.61) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7123906 | 0.86 | CYP1B1 (0.54) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7129139 | 0.86 | CYP1B1 (0.54) | CYP1B1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL7128627 | 0.86 | BRD1 (0.54) | CYP1B1MEN1KMT2ARAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667303-B1 | Agonists for serotonin 5-hydroxytryptamine 2C(5HT2C) receptor; 6-(1,4-diazepan-1-yl)benzo(cd)indol-2(1H)-ones, 6-(1,4-diazepan-1-yl)acenaphthylen-1(2H)-ones, and 5-(1,4-diazepan-1-yl)- 2H-naphtho(1,8-cd)isothiazole-1,1-dioxides | WYETH | 2003-12-23 | — | — | US | claimed |