Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121300 | 1.00 | HDAC2 (0.46) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10422570 | 0.89 | HDAC2 (0.55) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3668723 | 0.89 | AHR (0.52) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3851036 | 0.89 | AHR (0.52) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7129484 | 0.89 | CYP2C19 (0.45) | CYP1A2KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL1758044 | 0.84 | AHR (0.58) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1758043 | 0.84 | AHR (0.58) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3847986 | 0.81 | MAOB (0.54) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11091721 | 0.81 | MAOB (0.54) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3847989 | 0.81 | MAOB (0.54) | HDAC2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667346-B2 | Administration of a radioprotective alpha, beta unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces cytotoxic side effects of radiation on normal cells | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-23 | — | — | US | disclosed |